A new target for controlling inflammation? Long non-coding RNAs fine-tune the immune system

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Oct 01, 2014 10:15 PM EDT

Regulation of the human immune system's response to infection involves an elaborate network of complex signaling pathways that turn on and off multiple genes. The emerging importance of long noncoding RNAs and their ability to promote, fine-tune, and restrain the body's inflammatory response by regulating gene expression is described in a Review article in Journal of Interferon & Cytokine Research (JICR), a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the JICR website.

In the Review article "Transcription of Inflammatory Genes; Long Non-Coding RNA and Beyond," Susan Carpenter and Katherine Fitzgerald, University of Massachusetts Medical School, Worcester, MA, and University of California, San Francisco, CA, provide a detailed overview of the multi-layered gene regulation systems that are activated when the immune system recognizes a pathogen or other external danger signal. The growing understanding of the role that long noncoding RNAs play in regulating this complex circuitry could lead to their use as drug targets for developing selective antimicrobial therapeutics that do not cause damaging inflammation.

"This is a cutting-edge review from authors who are conducting pioneering research on the role of long non-coding RNAs in innate immune signaling," says Journal of Interferon & Cytokine Research Co-Editor-in-Chief Ganes C. Sen, PhD, Chairman, Department of Molecular Genetics, Cleveland Clinic Foundation, Ohio.

About the Journal

Journal of Interferon & Cytokine Research (JICR), led by Co-Editors-in-Chief Ganes C. Sen, PhD, Chairman, Department of Molecular Genetics, Cleveland Clinic Foundation, Ohio, and Thomas A. Hamilton, PhD, Chairman, Department of Immunology, Cleveland Clinic Foundation, Ohio, is an authoritative peer-reviewed journal published monthly online with Open Access options and in print that covers all aspects of interferons and cytokines from basic science to clinical applications. JICR is the official journal of the International Cytokine & Interferon Society. Complete tables of content and a sample issue may be viewed on the Journal of Interferon & Cytokine Researchwebsite.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Viral Immunology, AIDS Research and Human Retroviruses, and DNA and Cell Biology. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

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